Abstract
<jats:p>Introduction. In recent years, the evolution of acute glomerulonephritis in children has been accompanied by an early decline in renal function, with an increase in the frequency of latent and chronic variants of the disease. This situation requires serious attention to glomerulonephritis in children with various diseases (secondary immunodeficiency, allergic, metabolic) caused by environmental factors, which is a global problem. The aim of the study is to analyze the current features of the pathogenesis, epidemiology and clinical course of acute glomerulonephritis in children and the impact of environmental problems on it. Materials and methods. A retrospective review of the literature on acute glomerulopathies in children (including acute poststreptococcal glomerulonephritis (APSGN)) over the past decade was conducted. The data obtained was mathematically verified and compared by year. Results and discussion. APSGN in children is a serious problem today, and many aspects of the disease have not been fully resolved. Today, the real situation often differs radically from the traditional description of the disease. The reasons for the development of the pathological process in different clinical manifestations in individual patients and its severity remain unclear. Conclusion: In recent years, the leading etiological factor of OCSGN in children has been streptococcal infection, and the most typical clinical symptoms remain hematuria, generalized edema, and arterial hypertension. The development of the disease is often fundamentally dependent on the activation of a latent streptococcal infection in the body due to the influence of risk factors (ecology, hereditary predisposition to glomerulopathy, chronic foci of infection, the addition of a new viral-bacterial infection, secondary immunodeficiency, comorbidity of allergic, metabolic diseases).</jats:p>