Abstract
<jats:p> <jats:italic>Aim </jats:italic> To evaluate the prevalence of left ventricular hypertrophy (LVH) and its relationship with renal function parameters in patients with chronic kidney disease (CKD). </jats:p> <jats:p> <jats:italic>Material and methods </jats:italic> This cross-sectional retrospective cohort study included 1,080 patients with pre-dialysis CKD. The mean age was 39.0±12.9 years (17-74 years; median, 38 [28-49 years]). Patients were divided into three groups: Group 1 (n=381; GFR ≥60 mL/min/1.73 m²), Group 2 (n=181; GFR 59-30 mL/min/1.73 m²), and Group 3 (n=518; GFR ≤29 mL/min/1.73 m²). All patients underwent clinical and laboratory evaluation and echocardiography. Statistical analysis was performed using STATISTICA 10.0, utilizing Student's <jats:italic>t</jats:italic> -test, Mann-Whitney <jats:italic>U</jats:italic> test, ANOVA, and Spearman's correlation. Differences were considered statistically significant at <jats:italic>p</jats:italic> <0.05. </jats:p> <jats:p> <jats:italic>Results</jats:italic> The LV linear dimensions and mass index were significantly greater in patients with more pronounced renal impairment. Signs of LVH were identified in 489 patients (45.2%). The prevalence of LVH increased alongside the progression of CKD, reaching 8.8%, 26.5%, 35.5%, 35.1%, 52.7%, and 76.4% in stages C1-C5, respectively. Eccentric LVH was more prevalent than concentric LVH. LV mass index and relative wall thickness correlated significantly with both GFR and proteinuria levels. </jats:p> <jats:p> <jats:italic>Conclusion </jats:italic> Patients with CKD exhibit a high prevalence of LVH, which rises as the GFR declines and peaks at the advanced stages of the disease. LVH is predominantly eccentric. There is a statistically significant relationship between LV remodeling parameters and renal function, specifically GFR and proteinuria. </jats:p>