Abstract
<jats:p>Proteolytic enzymes from cold-adapted Antarctic hydrobionts (Sterechinus neumayeri and Odontaster validus) are a promising basis for the creation of new drugs that effectively treat purulent-necrotic wounds, as they are capable of highly active destruction of necrotic tissues of infected wounds. Our work aimed to evaluate the effect of a composition based on these enzymes on the healing dynamics and cytokine content in the blood serum of rats with purulent-necrotic wounds. The wounds were treated with a composition containing proteolytic enzymes isolated from Antarctic hydrobionts. The dynamics of wound healing and cytokine levels in the blood serum were analyzed. The results showed that the use of the enzyme composition accelerated wound healing and significantly influenced the cytokine profile, indicating activation of reparative processes and modulation of inflammatory reactions.</jats:p>