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<jats:title>Abstract</jats:title> <jats:p>How do we spark new scientific discoveries? Why do some breakthroughs seem even accidental? And most importantly, how can we accelerate them and push the boundaries of science? These are some of the biggest unsolved questions in science. Many believe breakthroughs arise by chance or serendipity. But here we show that it is powerful new tools and methods that enable discovering what we often did not even know existed: improved microscopes uncovered the hidden world of microorganisms and viruses, x-ray methods unlocked the structure of our DNA, particle accelerators detected subatomic particles that make up our world, and advanced telescopes revealed galaxies we never imagined. The Engine of Scientific Discovery explores, for the first time, science’s biggest discoveries—spanning all nobel-prize and major non-nobel discoveries throughout history. What we find is surprising: we have triggered science’s over 750 major discoveries by first inventing a new method or tool that made the breakthroughs possible—often within just a few years. This is because new tools enable us to see, measure and understand the world in ways that are impossible without them. From discovering planets beyond our solar system that reshape how we understand the universe, to CRISPR gene editing that transforms how we fight disease and cancer. This consistent pattern reveals a powerful insight: our transformative new methods and tools are The Engine of Scientific Discovery—a fundamental principle of scientific progress that has been overlooked until now. By shifting our focus to inventing new discovery tools, we can spark a method revolution in science. Instead of waiting for breakthroughs, we can actively design and build new tools of discovery. What if the next great breakthroughs depend not just on asking better questions, but on developing better tools to ask and answer them—on entirely new ways of discovering? A new theory of discovery emerges here, offering a roadmap to accelerate the pace of new breakthroughs across science. This book is for anyone who wants to understand how we make discoveries—and what drives science.</jats:p>

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